副教授 硕士生导师
个人邮箱:yuzhenyang3227@tongji.edu.cn
环境健康研究方向,采用秀丽线虫、黑腹果蝇为受试生物,基于环境真实暴露条件下的低浓度、长期、混合作用特征,开展传统、新兴、潜在环境污染物的健康危害与潜在机制研究。
教育经历:
2003-2007,南京大学,环境学院,环境生物专业,本科;
2007-2012,同济大学,环境科学与工程学院,环境科学专业,博士。
工作经历:
2012-2015,同济大学、瑞典斯德哥尔摩大学联合培养,博士后;
2012-2016,同济大学环境高等研究院,助理研究员;
2016-2019,同济大学环境科学与工程学院,助理教授;
2020-今,同济大学环境科学与工程学院,副教授。
主要科研项目:
国家自然科学基金面上项目:典型环境抗生素诱发肥胖效应与作用机理(21976138), 2020-2023,66.0万元,主持;
国家自然科学基金青年基金:典型抗生素多世代毒性效应及其表观遗传学机理研究(21307095),2014-2016,25.0万元,主持;
水体污染控制与治理科技重大专项子课题:嘉兴污染河网水源特征污染物风险评估及控制(2017ZX07201004-001),2017/01/01-2020/06/30,175.0万元,主持;
上海市科学技术委员会/上海市自然科学基金:水环境典型抗生素诱发肥胖效应与机制研究(17ZR1432500),2017/01/01-2019/12/31,20.0万元,主持;
中央高校基本科研业务费专项资金-学科交叉类重点项目:持久性有机污染物低剂量长期暴露导致的肿瘤迁移及其健康效应评价方法研究(22120180549,第二学科负责人),2018/10/01-2021/09/30,60.0万元,主持;
污染控制与资源化研究国家重点实验室资助课题:药物类化学品对端足虫Hyalella azteca生殖效应的性别差异及其抗氧化系统机制研究(PCRRIC16003),2016/07/01-2018/08/31,5.0万元,主持。
国家重点研发计划/政府间国际科技创新合作重点专项:长江下游水环境化学品风险评估与饮用水安全保障研究(2016YFE0123700),2017/01/01-2018/12/31,253.2万元,主要参与人。
国家自然科学基金重点项目:土壤结合态农药的生物可利用性与潜在毒性(21437004),2015-2019,350.0万元,主要参与人。
国家自然科学基金面上项目:基于鱼血模型研究几种典型人用药物的Readacross假设(21577103),2016-2019,65.0万元,参与。
国家自然科学基金面上项目:抗生素抗性基因在饮用水处理系统的分布特征、形成机制与控制方法(51278353),2013-2016,87.0万元,参与。
主要发表论文(2016年后):
Zhenyang Yu, LingYun Mo, Jing Zhang, ShuShen Liu, Time- and anion-dependent stimulation on triphosphopyridine nucleotide followed by antioxidant responses in Vibrio fischeri after exposure to 1-ethyl-3-methylimidazolium salts, Chemosphere 163 (2016) 452-460.
Zhenyang Yu, Jing Zhang, Time-dependent effects of [apyr]BF4 and key contributors to their mixture stimulation on Vibrio qinghaiensis sp.-Q67 at apical and biochemical levels, Journal of Hazardous Materials 312 (2016) 114-122.
Zhenyang Yu, Jing Zhang, DaQiang Yin, Multigenerational Effects of Heavy Metals on Feeding, Growth, Initial Reproduction and Antioxidants in Caenorhabditis elegans, PLoS ONE 11 (2016) e0154529.
Zhenyang Yu, Guohua Sun, Yanjun Liu, Daqiang Yin, Jing Zhang, Trans-generational influences of sulfamethoxazole on lifespan, reproduction and population growth of Caenorhabditis elegans, Ecotoxicology and Environmental Safety 135 (2017) 312-318.
Zhenyang Yu, Daqiang Yin, Meifang Hou, Jing Zhang, Effects of food availability on the trade-off between growth and antioxidant responses in Caenorhabditis elegans exposed to sulfonamide antibiotics, Chemosphere 211 (2018) 278-285.
Rui Chen, Zhenyang Yu(*), Daqiang Yin(*), Multi-generational effects of lindane on nematode lipid metabolism with disturbances on insulin-like signal pathway, Chemosphere 210 (2018) 607-614.
Zhenyang Yu, Jing Zhang, Meifang Hou, Time-dependent disturbances of chloride salts on overall redox reaction and luminescence in Vibrio fischeri, Chemosphere 199 (2018) 122-129,
Zhenyang Yu, Jing Zhang, Meifang Hou, The time-dependent stimulation of sodium halide salts on redox reactants, energy supply and luminescence in Vibrio fischeri, Journal of Hazardous Materials 342 (2018) 429-435.
Zhenyang Yu, Daqiang Yin, Jing Zhang, Sex-dependent effects of sulfamethoxazole exposure on pro-/antioxidant status with stimulation on growth, behavior and reproduction in the amphipod Hyalella Azteca, Environmental Pollution 244 (2019) 398-404.
Zhuo Li, Fangting Ai, Jing Zhang, Zhenyang Yu(*), Daqiang Yin. Using Caenorhabditis elegans for studying trans- and multi-generational effects of toxicants. Journal of Visualized Experiment (2019) e59367.
Aili Li, Tim aus der Beek, Michael Schubert, Zhenyang Yu, Thomas Schiedek, Christoph Schüth, Sedimentary archive of Polycyclic Aromatic Hydrocarbons and perylene sources in the northern part of Taihu Lake, China, Environmental Pollution 246 (2019) 198-206.
Caroline Ek, Andrius Garbaras, Zhenyang Yu, Hanna Oskarsson, Ann-Kristin Eriksson Wiklund, Linda Kumblad, Elena GorokhovaI, Increase in stable isotope ratios driven by metabolic alterations in amphipods exposed to the beta-blocker propranolol, PLoS ONE 14 (2019): e0211304.
Jing Zhang, Zhenyang Yu(*), Transgenerational effects of different sequential exposure to 2,2′,4,4′ tetra brominated diphenyl ether (BDE47) and lead (Pb) on Caenorhabditis elegans, Environmental Sciences Europe 32 (2020) 44.
Zhuo Li, Zhenyang Yu(*), Pin Gao, Daqiang Yin, Multigenerational effects of perfluorooctanoic acid on lipid metabolism of Caenorhabditis elegans and its potential mechanism, Science of the Total Environment 703 (2020) 134762.
Zhuo Li, Zhenyang Yu(*), Changzheng Cui, Fangting Ai, Daqiang Yin, Multi-generational obesogenic effects of sulfomethoxazole on Caenorhabditis elegans through epigenetic regulation, Journal of Hazardous Materials 382 (2020) 121061.
Zhenyang Yu, Jiaying Shen, Zhuo Li, Jinmin Yao, Wenzhe Li, Lei Xue, Laura Vandenberg, and Daqiang Yin, Obesogenic effect of sulfamethoxazole on Drosophila melanogaster with simultaneous disturbances on eclosion rhythm, glucolipid metabolism and microbiota, Environmental Science & Technology (2020) 10.1021/acs.est.9b07889.
沈佳颖, 于振洋(*), 尹大强, 李文哲, 林丹通过MAPK和UPR通路与干扰线粒体功能诱导黑腹果蝇(Drosophila melanogaster)肿瘤细胞迁移, 生态毒理学报 13 (2018) 97-109.
专利
一种黑腹果蝇肿瘤模型及其应用,专利申请号:201811599102.4,申请人:于振洋、沈佳颖、尹大强、史嘉琳、胡子欣、邱彬洋,申请日期:2018年12月26日,已授权;
一种利用秀丽隐杆线虫检测发育毒性的方法,专利申请号:201910699552.9,申请人:于振洋、艾芳婷、尹大强、孟祥周,申请日期:2019年7月31日。
学生指导成果:
已协助指导硕士毕业生3名、博士毕业生1名,其中1人获得上海市优秀毕业生称号、2人获得研究生国家奖学金。